The Gut Mycobiome in Parkinson’s Disease

The gut microbiome has been increasingly implicated in Parkinson’s disease (PD); however, most existing studies employ bacterial-specific sequencing, and have not investigated non-bacterial microbiome constituents. Here, we use fungal-specific internal transcribed spacer (ITS)-2 amplicon sequencing...

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Bibliographic Details
Published inJournal of Parkinson's disease Vol. 11; no. 1; pp. 153 - 158
Main Authors Cirstea, Mihai S., Sundvick, Kristen, Golz, Ella, Yu, Adam C., Boutin, Rozlyn C.T., Kliger, Daniel, Finlay, Brett B., Appel-Cresswell, Silke
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.2021
IOS Press BV
Subjects
Bacteria
Cognitive ability
Deoxyribonucleic acid
Digestive system
Digestive tract
DNA
Fungi
Intestinal microflora
Microbiomes
Movement disorders
Neurodegenerative diseases
Parkinson's disease
Fungal microbiome
mycobiome
gut microbiome
Parkinson’s disease
gut-brain axis
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Summary:The gut microbiome has been increasingly implicated in Parkinson’s disease (PD); however, most existing studies employ bacterial-specific sequencing, and have not investigated non-bacterial microbiome constituents. Here, we use fungal-specific internal transcribed spacer (ITS)-2 amplicon sequencing in a cross-sectional PD cohort to investigate associations between the fungal gut microbiome and PD. Fungal load among participants was extremely low, and genera identified were almost exclusively of proposed dietary or environmental origin. We observed significantly lower fungal DNA relative to bacterial DNA among PD patients. No fungi differed in abundance between patients and controls, nor were any associated with motor, cognitive, or gastrointestinal features among patients.
ISSN:1877-7171
1877-718X
DOI:10.3233/JPD-202237