Mitochondrial DNA repair pathways

DNA repair mechanisms are fairly well characterized for nuclear DNA while knowledge regarding the repair mechanisms operable in mitochondria is limited. Several lines of evidence suggest that mitochondria contain DNA repair mechanisms. DNA lesions are removed from mtDNA in cells exposed to various c...

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Bibliographic Details
Published inMutation research Vol. 434; no. 3; pp. 137 - 148
Main Authors Croteau, D L, Stierum, R H, Bohr, V A
Format Journal Article
LanguageEnglish
Published Netherlands 30.07.1999
Subjects
Aging - genetics
Alkylation
Animals
base excision repair
Cell Nucleus - metabolism
DNA Repair
DNA, Mitochondrial
Models, Biological
Mutation
Oxidative Stress
Rats
Recombination, Genetic
Uracil - metabolism
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Summary:DNA repair mechanisms are fairly well characterized for nuclear DNA while knowledge regarding the repair mechanisms operable in mitochondria is limited. Several lines of evidence suggest that mitochondria contain DNA repair mechanisms. DNA lesions are removed from mtDNA in cells exposed to various chemicals. Protein activities that process damaged DNA have been detected in mitochondria. As will be discussed, there is evidence for base excision repair (BER), direct damage reversal, mismatch repair, and recombinational repair mechanisms in mitochondria, while nucleotide excision repair (NER), as we know it from nuclear repair, is not present.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0027-5107
0921-8777
DOI:10.1016/S0921-8777(99)00025-7