Genetic effects of N-methyl- N′-nitro- N-nitrosoguanidine and its homologs

• Published in: Mutation research Vol. 99; no. 2; pp. 129 - 242
• Main Authors: Gichner, Tomáš, Velemínský, Jǐří
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.1982
• Subjects: Animals; Bacteria - drug effects; Bacteriophages - drug effects; Carcinogens; Cell Transformation, Neoplastic; DNA - metabolism; DNA Repair; DNA Replication - drug effects; Fungi - drug effects; Methylnitronitrosoguanidine - analogs & derivatives; Methylnitronitrosoguanidine - metabolism; Methylnitronitrosoguanidine - pharmacology; Mutagens; Mutation; Plasmids - drug effects; Proteins - metabolism; Teratogens; Viruses - drug effects; ENNG; pentyl NNG; O 6-EtG; iBNNG; CHO; 3-MeA; Cyd; PNNG; 3-MeC; octyl NNG; BNNG; MH; isopentyl NNG; ICR-191; 4NQO; MMC; BENNG; 3H-dThd; EMS; HGPRT; AZG; AP; MMS; NA; SCEs; V79; MNUr; 2-AP; MNNG; dThd; mtDNA; BrdUrd; ENU; BaP; O 6-MeG; MNU; SH; 3-EtC; hexyl NNG; DEB; ICR-170; SSB; DMN; 7-MeG; DMS; DEN; chloroethyl NNG; DES; TG; HA; TMV; TEM
• ISSN: 0165-1110; 0027-5107
• DOI: 10.1016/0165-1110(82)90057-4

Since the discovery of the mutagenic activity of N-methyl- N′-nitro- N-nitrosoguanidine (MNNG) in 1960, this compound has become one of the most widely used chemical mutagens. The present paper gives a survey on the chemistry, metabolism, and mode of interaction of MNNG with DNA and proteins, and of the genotoxic effects of this agent on microorganisms, plants, and animals, including human cells cultured in vitro. Data on the carcinogenicity and teratogenicity of MNNG as well as on the genotoxic effects of homologs of MNNG are also presented.