Intracellular recordings from burst-firing presumed serotonergic neurones in the rat dorsal raphe nucleus in vivo

Here we report the existence of burst-firing neurones in the rat dorsal raphe as detected in vivo using intracellular electrophysiological techniques. These neurones discharged single action potentials and doublets or triplets of action potentials in a slow and regular pattern. The apparent input re...

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Bibliographic Details
Published inBrain research Vol. 737; no. 1; pp. 308 - 312
Main Authors Hajós, Mihály, Sharp, Trevor, Newberry, Nigel R
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 21.10.1996
Subjects
5-HT neuron
Action Potentials - physiology
Animals
Dorsal raphe nucleus
Electrophysiology
Intracellular recording
Male
Neurons - physiology
Periodicity
Raphe Nuclei - cytology
Rats
Rats, Sprague-Dawley
Serotonin
Serotonin - physiology
Electrophysiology
5-HT neuron
Serotonin
Intracellular recording
Dorsal raphe nucleus
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Summary:Here we report the existence of burst-firing neurones in the rat dorsal raphe as detected in vivo using intracellular electrophysiological techniques. These neurones discharged single action potentials and doublets or triplets of action potentials in a slow and regular pattern. The apparent input resistance, action potential width and firing threshold of these burst-firing raphe neurones were indistinguishable from classical 5-HT neurones. Spike doublets were evoked by depolarising DC currents, but only in burst-firing neurones. These findings provide further evidence to support the hypothesis that 5-HT neurones (or a sub-set of them) are capable of burst-firing activity.
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ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(96)00936-5