Developing asymmetric iron and ruthenium-based cyclone complexes; complex factors influence the asymmetric induction in the transfer hydrogenation of ketones

The preparation of a range of asymmetric iron and ruthenium-cyclone complexes, and their application to the asymmetric reduction of a ketone, are described. The enantioselectivity of ketone reduction is influenced by a single chiral centre in the catalyst, as well as by the planar chirality in the c...

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Published inOrganic & biomolecular chemistry Vol. 10; no. 1; pp. 134 - 145
Main Authors Hopewell, Jonathan P., Martins, Jose E. D., Johnson, Tarn C., Godfrey, Jamie, Wills, Martin
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.01.2012
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ALCOHOLS
MECHANISM
ENANTIOSELECTIVE HYDROGENATION
TRANSITION-METAL
CATALYST
LIGAND
EFFICIENT
DYNAMIC KINETIC RESOLUTION
OPPENAUER-TYPE OXIDATION
HYDRIDE
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Summary:The preparation of a range of asymmetric iron and ruthenium-cyclone complexes, and their application to the asymmetric reduction of a ketone, are described. The enantioselectivity of ketone reduction is influenced by a single chiral centre in the catalyst, as well as by the planar chirality in the catalyst. This represents the first example of asymmetric ketone reduction using an iron cyclone catalyst.
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content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/c1ob06010d