The influence of peripheral connections on wallerian degeneration

Following electrophysiological techniques we investigated whether wallerian degeneration of the cat sural nerve may be influenced by (1) its peripheral connection and (2) the distance from the cell body. Distal stumps connected to their innervation sites peripherally showed less degeneration than pr...

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Bibliographic Details
Published inBrain research Vol. 525; no. 1; p. 152
Main Authors Delgado-Lezama, R, Muñoz-Martínez, E J
Format Journal Article
LanguageEnglish
Published Netherlands 13.08.1990
Subjects
Action Potentials - physiology
Animals
Cats
Electric Stimulation
Sural Nerve - anatomy & histology
Sural Nerve - physiology
Wallerian Degeneration - physiology
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Summary:Following electrophysiological techniques we investigated whether wallerian degeneration of the cat sural nerve may be influenced by (1) its peripheral connection and (2) the distance from the cell body. Distal stumps connected to their innervation sites peripherally showed less degeneration than proximal ones when isolated between two sections. However, when two isolated adjacent segments were produced by making 3 sections, the resulting degeneration was more pronounced in the distal segment. Thus, both the factors mentioned above appear to influence wallerian degeneration.
ISSN:0006-8993
DOI:10.1016/0006-8993(90)91332-B