Retinoic acid and homeobox gene regulation

Hox genes have been shown to be important regulators of pattern formation in vertebrates. Retinoic acid has been shown to affect the expression of Hox genes in vitro and in vivo, and some of its effects on development correspond to changes in Hox gene expression. The idea that retinoic acid is not s...

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Bibliographic Details
Published inCurrent opinion in genetics & development Vol. 4; no. 4; pp. 550 - 555
Main Authors Langston, Alexander W., Gudas, Lorraine J.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.1994
Subjects
Animals
Embryonic Induction - drug effects
Enhancer Elements, Genetic
Gene Expression Regulation, Developmental - drug effects
Genes, Homeobox - drug effects
Humans
Nervous System - embryology
Receptors, Retinoic Acid - metabolism
Teratocarcinoma - genetics
Transcriptional Activation
Tretinoin - pharmacology
Tumor Cells, Cultured - drug effects
RAR
ZPA
RARE
RXR
RA
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Summary:Hox genes have been shown to be important regulators of pattern formation in vertebrates. Retinoic acid has been shown to affect the expression of Hox genes in vitro and in vivo, and some of its effects on development correspond to changes in Hox gene expression. The idea that retinoic acid is not simply a powerful pharmacological agent, but rather that it plays an important role in creating the normal expression patterns of Hox genes, is provided by the recent identification of retinoic acid responsive enhancers near Hox genes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ISSN:0959-437X
1879-0380
DOI:10.1016/0959-437X(94)90071-A