Cytotoxic Thiophenes from the Root of Echinops grijisii Hance

A new thiophene, echinothiophenegenol (1), together with seven known thiophenes was isolated from the crude ethanol extract of roots of Echinops grijisii Hance. The structure of 1 was elucidated on the basis of spectroscopic data. Compounds 2 and 5, isolated from the plant for the first time, and co...

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Published inZeitschrift für Naturforschung C. A journal of biosciences Vol. 64; no. 3; pp. 193 - 196
Main Authors Zhang, Peng, Liang, Dong, Jin, Wenrong, Qu, Haibin, Cheng, Yiyu, Li, Xian, Ma, Zhongjun
Format Journal Article
LanguageEnglish
Published Germany Verlag der Zeitschrift für Naturforschung 01.03.2009
Subjects
Cell Survival - drug effects
Cytotoxic Activity
Echinops grijisii Hance
Echinops Plant - chemistry
Echinothiophenegenol
HL-60 Cells - drug effects
Humans
K562 Cells - drug effects
Models, Molecular
Molecular Conformation
Plant Roots - chemistry
Thiophenes - chemistry
Thiophenes - isolation & purification
Thiophenes - toxicity
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Summary:A new thiophene, echinothiophenegenol (1), together with seven known thiophenes was isolated from the crude ethanol extract of roots of Echinops grijisii Hance. The structure of 1 was elucidated on the basis of spectroscopic data. Compounds 2 and 5, isolated from the plant for the first time, and compounds 1 - 7 were tested for their cytotoxicity against two human cancer cell lines, HL60 and K562. The thiophenes showed better activity than the bithiophenes
ISSN:0939-5075
1865-7125
DOI:10.1515/znc-2009-3-407