Mycobacterium genavense Central Nervous System Infection in a Patient with AIDS

• Published in: Canadian journal of neurological sciences Vol. 50; no. 2; pp. 305 - 307
• Main Authors: Kuczynski, Andrea M., Krajden, Sigmund, Spears, Julian, Kus, Julianne V., Munoz, David G., Ostrowski, Mario, Chen, Yan, Supala-Berger, Agnes
• Format: Journal Article
• Language: English
• Published: New York, USA Cambridge University Press 01.03.2023
• Subjects: Abscesses; Acquired immune deficiency syndrome; Acquired Immunodeficiency Syndrome - complications; AIDS; Antibiotics; Biopsy; Central Nervous System Infections; Drug therapy; Edema; Histopathology; HIV; Human immunodeficiency virus; Humans; Immune system; Infections; Letter to the Editor: New Observation; Medical imaging; Mycobacterium; Nervous system; Neuroimaging; Patients; Tuberculosis; Immune reconstitution inflammatory syndrome; Mycobacterium genavense; Human immunodeficiency virus; Acquired immunodeficiency syndrome
• ISSN: 0317-1671; 2057-0155
• DOI: 10.1017/cjn.2022.6

Individuals with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) risk developing opportunistic infections including Mycobacterium tuberculosis complex (Mtbc) and organisms belonging to the Mycobacterium avium complex (MAC). MRI brain 10 days later demonstrated a reduction in mass size to 6 mm. Given atypical neuroimaging findings and negative serology, he was not started on Toxoplasmosis treatment. Direct PCR of biopsy material at 3 weeks post-craniotomy resulted in a 16S rRNA gene product (567 bp) with 99% match and hsp65 product (387 bp) with 100% match to M. genavense type strain 2289.