Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer

• Published in: Cancer letters Vol. 237; no. 2; pp. 289 - 297
• Main Authors: van der Jagt, Michel F.P., Sweep, Fred C.G.J., Waas, Erwin T., Hendriks, Thijs, Ruers, Theo J.M., Merry, Audrey H.H., Wobbes, Theo, Span, Paul N.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 18.06.2006; Elsevier Limited
• Subjects: Basigin - biosynthesis; Cell Survival; Colorectal cancer; Colorectal Neoplasms - enzymology; Colorectal Neoplasms - metabolism; Disease Progression; Extracellular matrix metalloproteinase inducer; Female; Gelatinase; Genetic Predisposition to Disease; GPI-Linked Proteins; Humans; Male; Matrix metalloproteinase; Matrix Metalloproteinase 2 - biosynthesis; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - biosynthesis; Matrix Metalloproteinase 9 - metabolism; Membrane Glycoproteins - biosynthesis; Nonsteroidal anti-inflammatory drugs; Prognosis; Reversion-inducing cysteine-rich protein with kazal motifs; RNA, Messenger - metabolism; Rodents; Survival analysis; Time Factors; Treatment Outcome; Tumors; Survival analysis; MMP; CRC; Reversion-inducing cysteine-rich protein with kazal motifs; EMMPRIN; Matrix metalloproteinase; Gelatinase; RECK; Extracellular matrix metalloproteinase inducer; ECM
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2005.06.009

mRNA, and latent and active levels MMP-2 and -9 were higher in tumor tissue compared to normal tissue from 63 patients with colorectal cancer, whereas RECK and EMMPRIN levels were lower. Correlations between mRNA, latent, and active MMP were particular high for MMP-2 in tumor tissue ( R s=0.6–0.8, P<0.001). For active MMP-2, but not for MMP-9, a significant negative partial correlation ( R p=−0.440, P<0.001) for RECK was found in tumor tissue, which was confirmed by linear regression analysis. In exploratory survival analyses we found that in patients with localized disease the RECK level in normal or tumor tissue had a significant ( P=0.017) association with overall survival.