Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina

Calcium channel blocker- (CCB-) associated peripheral edema does not resolve without CCB discontinuation or dose reduction. However, renin–angiotensin system (RAS) inhibitors have been reported to be effective for CCB-associated edema. We report a case of vasospastic angina with refractory CCB-assoc...

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Bibliographic Details
Published inCase reports in cardiology Vol. 2022; pp. 1 - 5
Main Authors Toda, Kojiro, Fujino, Masashi, Murai, Kota, Noguchi, Teruo
Format Journal Article
LanguageEnglish
Published New York Hindawi 08.07.2022
Hindawi Limited
Wiley
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Summary:Calcium channel blocker- (CCB-) associated peripheral edema does not resolve without CCB discontinuation or dose reduction. However, renin–angiotensin system (RAS) inhibitors have been reported to be effective for CCB-associated edema. We report a case of vasospastic angina with refractory CCB-associated edema. A 78-year-old man had refractory edema induced by a CCB. It was successfully treated with tolvaptan, an active vasopressin V2 receptor antagonist. The aim of this case report is to understand the mechanism and treatment of CCB-associated peripheral edema and how tolvaptan affects peripheral edema.
Bibliography:Academic Editor: Manabu Shirotani
ISSN:2090-6404
2090-6412
DOI:10.1155/2022/9550006