Lacidipine: A dihydropyridine calcium antagonist with antioxidant activity

Lacipidine, a new, long-acting antihypertensive dihydropyridine calcium antagonist was tested for potential antioxidant effect in series of tests that consider specific species. A direct quenching of several radical species could be measured. Moreover, in biological membranes deriving from rat brain...

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Published inFree radical biology & medicine Vol. 12; no. 3; pp. 183 - 187
Main Authors van Amsterdam, Frank Th.M., Roveri, Antonella, Maiorino, Matilde, Ratti, Emiliangelo, Ursini, Fulvio
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 1992
Subjects
Animals
Antioxidants
Calcium blocker
Calcium Channel Blockers - pharmacology
Cell Membrane - drug effects
Cell Membrane - metabolism
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Dihydropyridines - pharmacology
Drug Interactions
Free Radicals
Hypertension
Lacidipine
Lipid peroxidation
Lipid Peroxidation - drug effects
Male
Oxidants
Rats
Rats, Inbred Strains
Superoxides - chemistry
Hypertension
Antioxidants
Lipid peroxidation
Calcium blocker
Free radicals
Lacidipine
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Summary:Lacipidine, a new, long-acting antihypertensive dihydropyridine calcium antagonist was tested for potential antioxidant effect in series of tests that consider specific species. A direct quenching of several radical species could be measured. Moreover, in biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0891-5849
1873-4596
DOI:10.1016/0891-5849(92)90025-C