Interaction between raphe dorsalis and nucleus basalis magnocellularis in spatial learning

We compared the effects on spatial learning of an ibotenic acid lesion of the nucleus basalis magnocellularis (NBM), a 5, 7-dihydroxytryptamine lesion of the raphe dorsalis (RD) and a combined NBM and RD lesion. The RD lesion reduced serotonin levels, and the NBM lesion reduced cholineacetyltransfer...

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Bibliographic Details
Published inBrain research Vol. 527; no. 2; p. 342
Main Authors Riekkinen, Jr, P, Sirviö, J, Riekkinen, P
Format Journal Article
LanguageEnglish
Published Netherlands 17.09.1990
Subjects
Animals
Escape Reaction
Ibotenic Acid
Learning
Male
Olivary Nucleus - physiology
Raphe Nuclei - physiology
Rats
Rats, Inbred Strains
Reference Values
Space Perception
Stereotaxic Techniques
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Summary:We compared the effects on spatial learning of an ibotenic acid lesion of the nucleus basalis magnocellularis (NBM), a 5, 7-dihydroxytryptamine lesion of the raphe dorsalis (RD) and a combined NBM and RD lesion. The RD lesion reduced serotonin levels, and the NBM lesion reduced cholineacetyltransferase (ChAT) activity in the cortex. Although RD lesions alone did not affect spatial learning in the water-maze, the lesion aggravated the spatial navigation deficit produced by NMB lesioning. The current results suggest a functional interaction between the RD and NBM in spatial navigation.
ISSN:0006-8993
DOI:10.1016/0006-8993(90)91156-B