The immunohistochemical evidence of amyloid diffuse deposits as a pathological hallmark in Alzheimer's disease

We performed an immunocytochemical study of cerebral cortex from cases of Alzheimer's disease and from aged nondemented controls, using periodic acid pretreatment and polyclonal beta-protein antibodies. In addition to senile plaques (SP) and amyloid angiopathy (AA), the beta-protein antibodies...

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Bibliographic Details
Published inJournal of gerontology (Kirkwood) Vol. 46; no. 6; p. B209
Main Authors Behrouz, N, Defossez, A, Delacourte, A, Mazzuca, M
Format Journal Article
LanguageEnglish
Published United States 01.11.1991
Subjects
Aged
Aged, 80 and over
Aging - metabolism
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Amyloid - analysis
Amyloid beta-Peptides - analysis
Brain Chemistry
Cerebral Amyloid Angiopathy - metabolism
Cerebral Cortex - metabolism
Cerebral Cortex - pathology
Humans
Immunoenzyme Techniques
Immunohistochemistry
Periodic Acid
Staining and Labeling
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Summary:We performed an immunocytochemical study of cerebral cortex from cases of Alzheimer's disease and from aged nondemented controls, using periodic acid pretreatment and polyclonal beta-protein antibodies. In addition to senile plaques (SP) and amyloid angiopathy (AA), the beta-protein antibodies detected band-like deposits present throughout the cortical layers. Moreover, large plaque-like infiltrations with diffuse and amorphous characteristics were observed in the cortical gray and white matter, and these deposits were often associated with capillaries. Our results suggest that an abundance of these lesions, which were detected only with this immunostaining procedure in Alzheimer cortex, may be characteristic of Alzheimer's disease.
ISSN:0022-1422
DOI:10.1093/geronj/46.6.b209