MDSC parameter optimization for the determination of glass transitions using a Design of Experiments approach

Optimum experimental parameters for modulated differential scanning calorimetry were determined using a Design of Experiments approach. Two different strategies were tested, an isothermal method only varying modulation period and amplitude and a non-isothermal method including an underlying linear h...

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Bibliographic Details
Published inInternational journal of pharmaceutics Vol. 422; no. 1; pp. 271 - 279
Main Authors Xivillé, Núria Ruiz, Lorente, Laura Torre, Kordikowski, Andreas
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 17.01.2012
Subjects
Amorphous drugs
Angiotensin II Type 1 Receptor Blockers - chemistry
Calorimetry, Differential Scanning
Design of Experiments
differential scanning calorimetry
experimental design
Glass transition
heat
Lissajous figure
MDSC
Models, Statistical
Phase Transition
polymers
Pyrrolidines - chemistry
Reproducibility of Results
Research Design
Signal-To-Noise Ratio
sodium chloride
Sodium Chloride - chemistry
Technology, Pharmaceutical - methods
Tetrazoles - chemistry
Thermal analysis
Time Factors
Transition Temperature
Valine - analogs & derivatives
Valine - chemistry
Valsartan
Vinyl Compounds - chemistry
Glass transition
Amorphous drugs
Lissajous figure
MDSC
Design of Experiments
Thermal analysis
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Summary:Optimum experimental parameters for modulated differential scanning calorimetry were determined using a Design of Experiments approach. Two different strategies were tested, an isothermal method only varying modulation period and amplitude and a non-isothermal method including an underlying linear heating ramp. Three different test compounds were investigated including a blank of NaCl, a small pharmaceutically active molecule (Valsartan) and a polymer (PVP-VA 64). Obtained optimum values were found to be identical for each compound tested and shown to be statistically robust for repeated daily experimentation. Optimized signals showed lower glass transition values T g paired with higher changes in isobaric heat capacity Δ c p . Measured glass transition signals exhibited minimal variation during repeat analysis, and showed significantly better signal-to-noise ratios in comparison to literature data.
Bibliography:http://dx.doi.org/10.1016/j.ijpharm.2011.11.009
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2011.11.009