Cholecystokinin (CCK-8) elicits prandial sleep in rats

Electroencephalographic activity and behaviors were recorded in unrestrained adult rats during their first meal and intermeal interval following 17 hrs of food deprivation. Cholecystokinin (CCK-8), in doses of 5, 10, 20, 40, and 80 IDU/kg injected intraperitoneally 10 min after feeding began, suppre...

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Bibliographic Details
Published inPhysiology & behavior Vol. 30; no. 2; p. 179
Main Authors Mansbach, R S, Lorenz, D N
Format Journal Article
LanguageEnglish
Published United States 01.01.1983
Subjects
Animals
Cholecystokinin - pharmacology
Cortical Synchronization
Dose-Response Relationship, Drug
Eating - drug effects
Food Deprivation
Hypnotics and Sedatives - pharmacology
Male
Peptide Fragments - pharmacology
Rats
Rats, Inbred Strains
Reaction Time - drug effects
Sincalide
Sleep Stages - drug effects
Sleep, REM - drug effects
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Summary:Electroencephalographic activity and behaviors were recorded in unrestrained adult rats during their first meal and intermeal interval following 17 hrs of food deprivation. Cholecystokinin (CCK-8), in doses of 5, 10, 20, 40, and 80 IDU/kg injected intraperitoneally 10 min after feeding began, suppressed ingestion, elicited and prolonged rest behavior, synchronous wave sleep, and desynchronous wave sleep in a dose-related manner. The 80 IDU/kg dose elicited EEG and behavioral patterns indistinguishable from those of the postprandial control rats. The results suggest that cholecystokinin elicits satiety for food in rats, not illness. The results also suggest that EEG measures can be used to quantify the postprandial state of satiety.
ISSN:0031-9384
DOI:10.1016/0031-9384(83)90002-1