Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal

Skeletal muscle differentiation entails the coupling of muscle-specific gene expression to terminal withdrawal from the cell cycle. Several models have recently been proposed which attempt to explain how regulated expression and function of myogenic transcription factors ensures that proliferation a...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 6; no. 6; pp. 788 - 794
Main Authors Lassar, Andrew B., Skapek, Stephen X., Novitch, Bennett
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.1994
Subjects
Animals
Cell Cycle - genetics
Cell Cycle - physiology
Cell Differentiation - genetics
Cell Differentiation - physiology
Helix-Loop-Helix Motifs - physiology
Muscle, Skeletal - cytology
MyoD Protein - physiology
Oncogene Proteins - physiology
Rhabdomyosarcoma
Vertebrata
Rb
SV40 TAg
TGF
FGF
HLH
IGF
PKC
bHLH
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Summary:Skeletal muscle differentiation entails the coupling of muscle-specific gene expression to terminal withdrawal from the cell cycle. Several models have recently been proposed which attempt to explain how regulated expression and function of myogenic transcription factors ensures that proliferation and differentiation of skeletal muscle cells are mutually exclusive processes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:0955-0674
1879-0410
DOI:10.1016/0955-0674(94)90046-9