Differential activity of enantiomers of amphetamine in rats

Administration of single doses of d-amphetamine (0.5-4.0 mg/kg i.p.) to adult, male rats produced the expected dose-related increases in spontaneous motor activity. This effect was reduced by pretreatment with alpha-methylparatyrosine (alpha MT) and virtually unaffected by pretreatment with pargylin...

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Bibliographic Details
Published inNeuropharmacology Vol. 21; no. 12; p. 1323
Main Authors Maickel, R P, Light, K E, Zabik, J E
Format Journal Article
LanguageEnglish
Published England 01.01.1982
Subjects
alpha-Methyltyrosine
Amphetamine - pharmacology
Animals
Catecholamines - physiology
Dextroamphetamine - pharmacology
Fenclonine - pharmacology
Male
Methyltyrosines - pharmacology
Motor Activity - drug effects
Pargyline - pharmacology
Rats
Rats, Inbred Strains
Serotonin - physiology
Stereoisomerism
Time Factors
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Summary:Administration of single doses of d-amphetamine (0.5-4.0 mg/kg i.p.) to adult, male rats produced the expected dose-related increases in spontaneous motor activity. This effect was reduced by pretreatment with alpha-methylparatyrosine (alpha MT) and virtually unaffected by pretreatment with pargyline or parachlorophenylalanine (PCPA). Single doses of l-amphetamine (0.25-8.0 mg/kg) evoked an initial decrease in activity followed by increased activity of smaller magnitude than that caused by the d-isomer. The depressant effects of the l-isomer were prolonged by pretreatment with alpha MT, and abolished by pretreatment with pargyline or PCPA.
ISSN:0028-3908
DOI:10.1016/0028-3908(82)90141-1