Modulatory Effects of Black Tea Polyphenols on Rat Forestomach Carcinogenesis

ABSTRACT The present study was designed to evaluate the chemopreventive effects of black tea polyphenols (Polyphenon-B) on N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in Wistar rats. Intragastric administration of MNNG induced well-differentiated squamous cell carcinom...

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Published inToxicology mechanisms and methods Vol. 17; no. 8; pp. 467 - 474
Main Authors Murugan, R. Senthil, Mohan, K.V.P. Chandra, Nagini, S.
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.01.2007
Taylor & Francis
Subjects
Antioxidants
Black Tea Polyphenols
Chemoprevention
Gastric Cancer
Lipid Peroxidation
Mitochondria
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Summary:ABSTRACT The present study was designed to evaluate the chemopreventive effects of black tea polyphenols (Polyphenon-B) on N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in Wistar rats. Intragastric administration of MNNG induced well-differentiated squamous cell carcinomas that showed diminished mitochondrial lipid and protein oxidation and an increase in antioxidants. In contrast to tumor tissue, the liver mitochondria of tumor-bearing animals showed elevated lipid and protein oxidation with compromised antioxidant defenses. Dietary administration of Polyphenon-B effectively suppressed MNNG-induced stomach tumors, modulated mitochondrial lipid and protein oxidation, and enhanced antioxidant enzyme activities in the stomach and liver. Our results suggest that Polyphenon-B may exert its chemopreventive effects by modulating mitochondrial cellular redox status in the tumor as well as in the host liver.
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ISSN:1537-6516
1537-6524
DOI:10.1080/15376510701190797