The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves’ Orbitopathy

• Published in: Investigative ophthalmology & visual science Vol. 64; no. 11; p. 13
• Main Authors: Byeon, Hyeong Ju, Chae, Min Kyung, Ko, JaeSang, Lee, Eun Jig, Kikkawa, Don O., Jang, Sun Young, Yoon, Jin Sook
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 01.08.2023
• Subjects: Adipogenesis; Adipokines - metabolism; Biochemistry and Molecular Biology; CD40 Ligand; Cells, Cultured; Complement Factor D - genetics; Cytokines - metabolism; Fibroblasts - metabolism; Graves Ophthalmopathy - metabolism; Humans; Insulin-Like Growth Factor I - metabolism; Interleukin-6 - metabolism; Orbit - metabolism
• ISSN: 1552-5783; 0146-0404; 1552-5783
• DOI: 10.1167/iovs.64.11.13

Graves' orbitopathy (GO) is an orbital manifestation of autoimmune Graves' disease, and orbital fibroblast is considered a target cell, producing pro-inflammatory cytokines and/or differentiating into adipocytes. Adipose tissue has been focused on as an endocrine and inflammatory organ sec...