Pretreatment of Shaoyao Gancao Decoction(芍药甘草汤)Alters Pharmacokinetics of Intravenous Paclitaxel in Rats

• Published in: Chinese journal of integrative medicine Vol. 23; no. 1; pp. 70 - 75
• Main Authors: Wang, Yang, Huang, Xi, Zhong, Mei-zuo, Lu, Ruo-huang, Xia, Zi-an, Fan, Rong, Liu, Bo, Huang, Wei, Gan, Ping-ping
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 2017
• Subjects: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - therapeutic use; Herb-Drug Interaction; Injections, Intravenous; Male; Medicine; Medicine & Public Health; Paclitaxel - administration & dosage; Paclitaxel - blood; Paclitaxel - chemistry; Paclitaxel - pharmacokinetics; Rats, Sprague-Dawley; Reference Standards; Time Factors; paclitaxel; drug interactions; Shaoyao Gancao Decoction; pharmacokinetic
• ISSN: 1672-0415; 1993-0402
• DOI: 10.1007/s11655-016-2619-6

Objective:To investigate the effect of Shaoyao Gancao Decoction（芍药甘草汤,SGD） on the pharmacokinetics of intravenously administered paclitaxel in rats.Methods:Paclitaxel was intravenously administered to rats（3 mg/kg） with or without the concomitant administration of SGD（752 mg/kg,a single day or 14 consecutive days pretreatment）.The paclitaxel in the serum was quantified using a simple and rapid ultra performance liquid chromatography（UPLC） method for the pharmacokinetic study.The pharmacokinetic parameters were calculated via a non-compartment model using the computer program DAS 2.0.Results:The pharmacokinetic parameters of paclitaxel were significantly altered in response to 14 consecutive days of pretreatment with SGD.The area under the curve(AUC0-t,from 4 820 ± 197 to 4 205 ± 186 ng·mL-1·h-1)and AUC0-∞(from 5 237 ±280 to 4 514 ± 210 ng·mL-1·h-1) significantly decreased in response to the 14-day pretreatment with SGD.The values of Vdss（L/kg） were 10.74 ±1.08 and 9.35 ±0.49,those of CL（L/kg） were0.67 ±0.03 and 0.57 ±0.03 and the t1/2（h） values were 11.17 ±0.84 and 11.32 ±0.93,respectively,for the14-day SGD pretreatment and intravenous paclitaxel alone.The AUC0-t and AUC0-∞ values decreased by13%and 14%（P<0.01）,respectively.The area under the curve decreased significantly（P<0.01）,and the total clearance increased by 1.2-fold（P<0.01）,after 14 consecutive days of pretreatment with SGD.A single-day pretreatment with SGD did not significantly affect the pharmacokinetic parameters of paclitaxel.Conclusions:SGD administration for 14 consecutive days increased the metabolism of paclitaxel,while a 1-day pretreatment had little effect.The results would contribute important information to the study on interaction between Chinese medicines and chemotherapy and also help to utilize SGD better in the adjunctive therapy of cancer patients.