HLA and systemic lupus erythematosus in Chinese

Seventy-five unrelated Chinese SLE patients were HLA typed and subdivided into mild and severe disease The HLA-B13 was associated with mild disease Fourteen of 30 (46.7%) mild disease patients had B13 compared to 63/330 (19.1%) normal subjects ( p < 0 0005, corrected p < 0 013, RR = 3 7) The H...

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Published inHuman immunology Vol. 3; no. 4; pp. 345 - 350
Main Authors Chan, S.H., Feng, P.H., Srinivasan, N., Wee, G.B., Chan, H.C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1981
Subjects
China
HLA Antigens - genetics
HLA Antigens - immunology
Humans
Lupus Erythematosus, Systemic - epidemiology
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - mortality
China
NPC
RR
EBV
HLA
SLE
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Summary:Seventy-five unrelated Chinese SLE patients were HLA typed and subdivided into mild and severe disease The HLA-B13 was associated with mild disease Fourteen of 30 (46.7%) mild disease patients had B13 compared to 63/330 (19.1%) normal subjects ( p < 0 0005, corrected p < 0 013, RR = 3 7) The HLA-B17 on the other hand was observed in 29% of 45 severe disease patients compared to 13 9% of 330 normal subjects ( p < 0 01, RR = 2.5). The frequency of HLA-B17 in 11 patients who died was even higher (45 5%).
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ISSN:0198-8859
1879-1166
DOI:10.1016/0198-8859(81)90070-7