Tolerance and antiviral effect of ribavirin in patients with Argentine hemorrhagic fever

Tolerance and antiviral effect of ribavirin was studied in 6 patients with Argentine hemorrhagic fever (AHF) of more than 8 days of evolution. Administration of ribavirin resulted in a neutralization of viremia and a drop of endogenous interferon titers. The average time of death was delayed. A reve...

Full description

Saved in:
Bibliographic Details
Published inAntiviral research Vol. 7; no. 6; p. 353
Main Authors Enria, D A, Briggiler, A M, Levis, S, Vallejos, D, Maiztegui, J I, Canonico, P G
Format Journal Article
LanguageEnglish
Published Netherlands 01.07.1987
Subjects
Anemia - chemically induced
Female
Hematocrit
Hemoglobins - analysis
Hemorrhagic Fever, American - drug therapy
Humans
Interferons - analysis
Male
Prospective Studies
Ribavirin - adverse effects
Ribavirin - therapeutic use
Ribonucleosides - therapeutic use
Viremia - drug therapy
Online AccessGet more information

Cover

More Information
Summary:Tolerance and antiviral effect of ribavirin was studied in 6 patients with Argentine hemorrhagic fever (AHF) of more than 8 days of evolution. Administration of ribavirin resulted in a neutralization of viremia and a drop of endogenous interferon titers. The average time of death was delayed. A reversible anemia was the only adverse effect observed. From these results, we conclude that ribavirin has an antiviral effect in advanced cases of AHF, and that anemia, the only secondary reaction observed, can be easily managed. The possible beneficial effect of ribavirin during the initial days of AHF is discussed.
ISSN:0166-3542
DOI:10.1016/0166-3542(87)90017-9