Apomorphine and glycoprotein synthesis during consolidation

The dopamine agonist, apomorphine, was injected intrahippocampally immediately after acquisition of a brightness discrimination task, which was motivated by footshock in rats. This led to an increase in the incorporation of L-fucose into total proteins which were measured in the hippocampus 7–9 hour...

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Published inPharmacology, biochemistry and behavior Vol. 17; no. 1; pp. 11 - 13
Main Authors Jork, R., Grecksch, Gisela, Matthies, H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1982
Subjects
Animals
Apomorphine
Apomorphine - pharmacology
Ascorbic Acid - pharmacology
Consolidation
Discrimination Learning - physiology
Fucose - metabolism
Glycoprotein synthesis
Glycoproteins - biosynthesis
Hippocampus
Hippocampus - metabolism
Learning - drug effects
Learning - physiology
Male
Nerve Tissue Proteins - biosynthesis
Rat
Rats
Rats, Inbred Strains
Consolidation
Rat
Hippocampus
Apomorphine
Glycoprotein synthesis
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Summary:The dopamine agonist, apomorphine, was injected intrahippocampally immediately after acquisition of a brightness discrimination task, which was motivated by footshock in rats. This led to an increase in the incorporation of L-fucose into total proteins which were measured in the hippocampus 7–9 hours later. In behavioral experiments, the same application improved the retention of a learned task. A possible linkage between increased glycoprotein synthesis and improvement of the retention of a new learned behavior due to the action of apomorphine is discussed.
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ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(82)90254-4