Total synthesis of grayanane natural products

Grayananes are a broad family of diterpenoids found in plants, comprising more than 160 natural products. Most of them exhibit interesting biological activities, often representative of use in traditional medicine. Over the last 50 years, various strategies were described for the total synthesis of...

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Published inBeilstein journal of organic chemistry Vol. 18; pp. 1707 - 1719
Main Authors Fay, Nicolas, Blieck, Rémi, Kouklovsky, Cyrille, de la Torre, Aurélien
Format Journal Article
LanguageEnglish
Published Germany Beilstein-Institut zur Föerderung der Chemischen Wissenschaften 2022
Beilstein-Institut
Subjects
Alcohol
Analgesics
Chemical Sciences
Diterpenes
Ericaceae
Natural products
Oxidation
enantioselectivity
grayananes
1,2-shift
oxidation
total synthesis
2-shift
enantioselectivity grayananes oxidation 1
1
2-shift total synthesis
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Summary:Grayananes are a broad family of diterpenoids found in plants, comprising more than 160 natural products. Most of them exhibit interesting biological activities, often representative of use in traditional medicine. Over the last 50 years, various strategies were described for the total synthesis of these diterpenoids. In this review, we survey the literature for synthetic approaches to access grayanane natural products. We will focus mainly on completed total syntheses, but will also mention unfinished synthetic efforts. This work aims at providing a critical perspective on grayanane synthesis, highlighting the advantages and downsides of each strategy, as well as the challenges remaining to be tackled.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.18.181