Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor

Kynurenate produces an unsurmountable antagonism of the response to N-methyl-D-aspartate (NMDA) in the baby rat hemisected spinal cord. This effect is completely reversible and prevented by co-superfusion with D-serine or glycine in the presence of strychnine. In the presence of D-serine kynurenate...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 154; no. 1; p. 85
Main Authors Birch, P J, Grossman, C J, Hayes, A G
Format Journal Article
LanguageEnglish
Published Netherlands 01.09.1988
Subjects
Animals
Aspartic Acid - analogs & derivatives
Aspartic Acid - antagonists & inhibitors
Dose-Response Relationship, Drug
Glycine - pharmacology
In Vitro Techniques
Kynurenic Acid - pharmacology
N-Methylaspartate
Rats
Rats, Inbred Strains
Receptors, Glycine
Receptors, Neurotransmitter - drug effects
Serine - pharmacology
Strychnine - pharmacology
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Summary:Kynurenate produces an unsurmountable antagonism of the response to N-methyl-D-aspartate (NMDA) in the baby rat hemisected spinal cord. This effect is completely reversible and prevented by co-superfusion with D-serine or glycine in the presence of strychnine. In the presence of D-serine kynurenate acts as a weak competitive antagonist. The results suggest that one of the actions of kynurenate is to antagonise NMDA responses via an action at the strychnine-insensitive glycine receptor.
ISSN:0014-2999
DOI:10.1016/0014-2999(88)90367-6