Grindelane derivatives by microbial transformation

• Published in: Phytochemistry (Oxford) Vol. 30; no. 6; pp. 1847 - 1848
• Main Authors: Aladesanmi, Adetunji J., Hoffmann, Joseph J.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 1991; Elsevier
• Subjects: 18-hydroxygrindelic acid; 3-ketogrindelic acid; 7 alpha, 8 alpha-epoxygrindelic acid; 7α,8α-epoxygrindelic acid; Aspergillus niger; Asteraceae; Bioconversions. Hemisynthesis; Biological and medical sciences; Biotechnology; biotransformation; Fundamental and applied biological sciences. Psychology; Grindelia; Grindelia camporum; labdanes; metabolism; Methods. Procedures. Technologies; methyl-3-alpha-hydroxygrindelate; methyl-3-α-hydroxygrindelate; biotransformation; 7α,8α-epoxygrindelic acid; Grindelia camporum; Aspergillus niger; Asteraceae; methyl-3-α-hydroxygrindelate; 3-ketogrindelic acid; 18-hydroxygrindelic acid; Fungi; Characterization; Fungi Imperfecti; Biotransformation; Thallophyta
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/0031-9422(91)85026-V

The microbial transformation of grindelic acid by a culture of Aspergillus niger produced 3-ketogrindelic acid and the known grindelanes: 18-hydroxygrindelic acid, 7α,8α-epoxygrindelic acid and methyl-3-β-hydroxygrindelate.