Acanthocheilonema viteae in Mastomys coucha: Chemotherapeutic and Chemoprophylactic Role of Vitamin A in Experimental Filarial Infection

The role of vitamin A was evaluated for its chemotherapeutic and chemoprophylactic action against Acanthocheilonema viteae infection in Mastomys coucha. Vitamin A was administered for 10 days, five days before infection and five days post infection. On day 0 experimental animals as well as controls...

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Published inZeitschrift für Naturforschung C. A journal of biosciences Vol. 61; no. 3; pp. 285 - 288
Main Authors Bhatnagara, Sunita, Bhattacharya, Shailja, Chatterjee, R. K.
Format Journal Article
LanguageEnglish
Published Germany Verlag der Zeitschrift für Naturforschung 01.03.2006
Subjects
Acanthocheilonema viteae
Animals
Anthelmintics - isolation & purification
Cell Movement - drug effects
Female
Filariasis - prevention & control
Lymphocytes - drug effects
Lymphocytes - physiology
Mansonella - isolation & purification
Mansonella - physiology
Mastomys coucha
Murinae - parasitology
Uterus
Vitamin A
Vitamin A - therapeutic use
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Summary:The role of vitamin A was evaluated for its chemotherapeutic and chemoprophylactic action against Acanthocheilonema viteae infection in Mastomys coucha. Vitamin A was administered for 10 days, five days before infection and five days post infection. On day 0 experimental animals as well as controls were infected with L3, the infective stage. Establishment of the worms revealed significantly less percentage of worm recovery over untreated controls. Cell-mediated response was found to be the cause of this reduction in worm recovery, whereas humoral response was not significant as lgG, lgA and lgM titres were low.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0939-5075
1865-7125
DOI:10.1515/znc-2006-3-422