Palisaded encapsulated neuroma in tongue - A commonly misdiagnosed peripheral nerve sheath tumor

Palisaded encapsulated (solitary circumscribed) neuromas are benign neural tumors, rarely found in oral mucosa. This case reports a 24-year-old man that presented a unique soft nodule at the left side of the tongue. An excisional biopsy was performed under local anesthesia and histopathological exam...

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Bibliographic Details
Published inIndian journal of pathology & microbiology Vol. 63; no. 4; pp. 604 - 607
Main Authors Assao, Agnes, Pereira, Michele, Cury, Álvaro, Soares, Cléverson, Oliveira, Denise
Format Journal Article
LanguageEnglish
Published Mumbai Wolters Kluwer India Pvt. Ltd 01.10.2020
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects
Analysis
Anesthesia
Biopsy
Case reports
CD57 antigen
Collagen
Collagen (type IV)
Diagnosis
Differential diagnosis
Encapsulation
immunohistochemistry
Mucosa
Nodules
Peripheral nerves
Schwann cells
Sheaths
Stroma
Tongue
traumatic neuroma
Tumors
Immunohistochemistry
tongue
traumatic neuroma
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Summary:Palisaded encapsulated (solitary circumscribed) neuromas are benign neural tumors, rarely found in oral mucosa. This case reports a 24-year-old man that presented a unique soft nodule at the left side of the tongue. An excisional biopsy was performed under local anesthesia and histopathological examination of the surgical specimen revealed a well circumscribed mass composed of spindled Schwann cells, often aligned and fasciculated, forming occasional nodules embedded in a fibrous stroma. Histopathological analysis showed the presence of positive cells for S-100, EMA, CD57, and collagen IV. Based on clinical and microscopical features, the diagnosis established was of palisaded encapsulated neuroma. This case report aims to discuss the differential diagnosis among palisaded encapsulated neuroma and the other neural tumors that affect the oral mucosa.
ISSN:0377-4929
0974-5130
DOI:10.4103/IJPM.IJPM_515_19