Crimean‐Congo hemorrhagic fever: Five patients with hemophagocytic syndrome

• Published in: American journal of hematology Vol. 83; no. 1; pp. 73 - 76
• Main Authors: Tasdelen Fisgin, Nuriye, Fisgin, Tunc, Tanyel, Esra, Doganci, Levent, Tulek, Necla, Guler, Nil, Duru, Feride
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2008; Wiley-Liss
• Subjects: Adolescent; Aged; Arboviral haemorrhagic fevers; Arboviroses; Biological and medical sciences; Bone Marrow - pathology; Child, Preschool; Female; Hematologic and hematopoietic diseases; Hemorrhagic Fever, Crimean - pathology; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Middle Aged; Phagocytes - pathology; Syndrome; Tropical viral diseases; Viral diseases; Infection; Human; Hemophagocytic syndrome; Hematology; Viral disease; Arbovirus disease; Congo-Crimean haemorrhagic fever; Hemopathy; Histiocytosis
• ISSN: 0361-8609; 1096-8652
• DOI: 10.1002/ajh.20969

Three pediatric and two adult Turkish patients with Crimean Congo Hemorrhagic Fever (CCHF) induced hemophagocytic syndrome (HPS) were admitted to Ondokuz Mayis University Hospital, which is in the Middle Black Sea Region of Turkey. All of them had remarkable hemophagocytosis in the bone marrow with severe bleeding symptoms along with the other known clinical and laboratory findings of CCHF. We would like to present these patients and to discuss the pathophysiology and the effect of acquired HPS on the severity of the disease. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.