Bioactive bacterial cellulose sulfate electrospun nanofibers for tissue engineering applications

Cellulosic materials have been of tremendous importance to mankind since its discovery due to its superior properties and its abundance in nature. Recently, an increase in demand for alternate green materials has rekindled the interest for cellulosic materials. Here, bacterial cellulose has been fun...

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Published inJournal of tissue engineering and regenerative medicine Vol. 12; no. 7; pp. 1634 - 1645
Main Authors Palaninathan, Vivekanandan, Raveendran, Sreejith, Rochani, Ankit K., Chauhan, Neha, Sakamoto, Yasushi, Ukai, Tomofumi, Maekawa, Toru, Kumar, D. Sakthi
Format Journal Article
LanguageEnglish
Published England Hindawi Limited 01.07.2018
Subjects
Alcohols
Antioxidants
Bacteria
bacterial cellulose
bacterial cellulose sulfate
Biocompatibility
Cell adhesion
Cell adhesion & migration
Cellulose
Chemical industry
electrospinning
Fibers
Nanofibers
Oxidative stress
Polyvinyl alcohol
Regenerative medicine
Sulfates
Sustainable materials
Tissue engineering
antioxidants
electrospinning
bacterial cellulose
bacterial cellulose sulfate
nanofibers
oxidative stress
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Summary:Cellulosic materials have been of tremendous importance to mankind since its discovery due to its superior properties and its abundance in nature. Recently, an increase in demand for alternate green materials has rekindled the interest for cellulosic materials. Here, bacterial cellulose has been functionalized with sulfate groups through acetosulfation to gain solubility in aqueous media, which provides access to several applications. The cell viability, antioxidant, and hemocompatibility assays have verified the biocompatible and antioxidant characteristics of bacterial cellulose sulfate (BCS) in both in vitro and ex vivo conditions. Further, novel BCS/polyvinyl alcohol nanofibers were fabricated by simple electrospinning route to engineer ultrafine nanoscale fibers. The biological evaluation of BCS/polyvinyl alcohol nanofiber scaffolds was done using L929 mouse fibroblast cells, which confirmed that these nanofibers are excellent matrices for cell adhesion and proliferation.
Bibliography:ObjectType-Article-1
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ISSN:1932-6254
1932-7005
DOI:10.1002/term.2689