Effectiveness of a Community‐Based Weight Management Program for Patients Taking Antidepressants and/or Antipsychotics

• Published in: Obesity (Silver Spring, Md.) Vol. 27; no. 9; pp. 1539 - 1544
• Main Authors: Wharton, Sean, Kuk, Jennifer L., Petrova, Lana, Rye, Peter I., Taylor, Valerie H., Christensen, Rebecca A.G.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.09.2019
• Subjects: Antidepressants; Antidepressive Agents - adverse effects; Antipsychotic Agents - adverse effects; Antipsychotics; Female; Gastrointestinal surgery; Humans; Male; Middle Aged; Obesity; Psychotropic drugs; Systematic review; Weight Loss - physiology; Weight Reduction Programs - methods; Ontario Canada; Canada; United States > US
• ISSN: 1930-7381; 1930-739X
• DOI: 10.1002/oby.22567

Objective This study aimed to compare weight loss (WL) outcomes for patients taking antidepressants and/or antipsychotics with those not taking psychiatric medication. Methods A total of 17,519 adults enrolled in a lifestyle WL intervention at the Wharton Medical Clinics in Ontario, Canada, were analyzed. Sex‐stratified multivariable linear regression analysis was used to examine the association of taking antidepressants, antipsychotics, both, or neither with WL when adjusting for age, initial weight, and treatment time. Results Twenty‐three percent of patients were taking at least one psychiatric medication. Patients lost a significant amount of weight (P < 0.0001) regardless of psychiatric medication use. Women taking psychiatric medications lost a similar amount of weight as women who were not (P > 0.05). Conversely, men taking antidepressants lost only slightly less weight than men taking both classes or neither class of psychiatric medication (3.2 ± 0.3 kg vs. 5.6 ± 0.9 kg and 4.3 ± 0.1 kg; P < 0.05). However, taking psychiatric medications that cause weight gain was associated with similar significant decreases in weight as taking medications that are weight neutral or associated with WL for both sexes (P > 0.05). Conclusions Results of this study suggest that those who participate in a weight management program can lose significant amounts of weight regardless of psychiatric medication use.