Prevention of aflatoxin B1 toxicity by pomegranate peel extract and its effects on growth, blood biochemical changes, oxidative stress and histopathological alterations

• Published in: Journal of animal physiology and animal nutrition Vol. 108; no. 1; pp. 174 - 184
• Main Authors: Imbabi, Tharwat A., El‐Sayed, Abdelkarim I. M., Radwan, Ahmed A., Osman, Ali, Abdel‐Samad, Asmaa M.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.01.2024
• Subjects: aflatoxin; Aflatoxin B1; Aflatoxin B1 - toxicity; Aflatoxins; Animal feed; Animal Feed - analysis; Animal nutrition; Animals; Contamination; Diet; Diet - veterinary; Feeds; Liver - metabolism; Mycotoxins; New Zealand White rabbits; Oxidative Stress; Oxytetracycline; Plant extracts; Pomegranate - metabolism; pomegranate peel extract; Rabbits; Toxicity; New Zealand White rabbits; pomegranate peel extract; oxytetracycline; aflatoxin
• ISSN: 0931-2439; 1439-0396
• DOI: 10.1111/jpn.13877

Contamination of animal feeds with mycotoxins is one of the most serious issues in the world of animal nutrition. The purpose of this study was to assess the efficacy of pomegranate peel extract (PPE) versus oxytetracycline (OXY) in reducing aflatoxin B1 (AFB1) toxicity in rabbits fed contaminated diets. This experiment was done on 48 weaned NZW, four groups (n = 12). The first (AF) served as the control group feed on an infected diet by AFB1 between 0.02 and 0.03 mg/kg BW; second (AF + OXY) received an infected diet by AFB1 and was treated with OXY 200 mg/kg BW/day; third (AF + PPE) received an infected diet by AFB1 and treated with PPE 130 mg/kg BW/day; fourth (AF + OXY + PPE) received an infected diet by AFB1 and treated with a daily oral dose of 100 mg/kg BW/day of OXY + PPE (65 mg/kg BW/day), the experiment lasted for 8 weeks experiment. The treated group with PPE and its combination with OXY concurrent with AF showed amelioration markedly for liver and kidney function. To summarise, adding PPE and combining it with OXY at a half dose to an AFB1‐contaminated diet can help minimise the harmful effects of AFB1 on rabbit performance.