Impact of uncertainties in biometric parameters on intraocular lens power formula predicted refraction using a Monte‐Carlo simulation

• Published in: Acta ophthalmologica (Oxford, England) Vol. 102; no. 3; pp. e285 - e295
• Main Authors: Langenbucher, Achim, Hoffmann, Peter, Cayless, Alan, Bolz, Matthias, Wendelstein, Jascha, Szentmáry, Nóra
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2024
• Subjects: biometric measures; Biometrics; Biometry - methods; Cataract; Cataracts; Cornea; error propagation; Eye surgery; Humans; Intraocular lenses; IOL formula predicted refractive outcome; ISO labelling tolerances; Labeling; Lens Implantation, Intraocular; Lenses, Intraocular; Monte–Carlo simulation; Optics and Photonics; Phacoemulsification; Refraction, Ocular; Retrospective Studies; Standard deviation; Surgery; Uncertainty; Visual Acuity; within‐subject standard deviation; error propagation; biometric measures; ISO labelling tolerances; IOL formula predicted refractive outcome; Monte–Carlo simulation; within‐subject standard deviation
• ISSN: 1755-375X; 1755-3768; 1755-3768
• DOI: 10.1111/aos.15726

Purpose The purpose of this study was to investigate the uncertainty in the formula predicted refractive outcome REFU after cataract surgery resulting from measurement uncertainties in modern optical biometers using literature data for within‐subject standard deviation Sw. Methods This Monte–Carlo simulation study used a large dataset containing 16 667 preoperative IOLMaster 700 biometric measurements. Based on literature Sw values, REFU was derived for both the Haigis and Castrop formulae using error propagation strategies. Using the Hoya Vivinex lens (IOL) as an example, REFU was calculated both with (WLT) and without (WoLT) consideration of IOL power labelling tolerances. Results WoLT the median REFU was 0.10/0.12 dpt for the Haigis/Castrop formula, and WLT it was 0.13/0.15 dpt. WoLT REFU increased systematically for short eyes (or high power IOLs), and WLT this effect was even more pronounced because of increased labelling tolerances. WoLT the uncertainty in the measurement of the corneal front surface radius showed the largest contribution to REFU, especially in long eyes (and low power IOLs). WLT the IOL power uncertainty dominated in short eyes (or high power IOLs) and the uncertainty of the corneal front surface in long eyes (or low power IOLs). Conclusions Compared with published data on the formula prediction error of refractive outcome after cataract surgery, the uncertainty of biometric measures seems to contribute with ⅓ to ½ to the entire standard deviation. REFU systematically increases with IOL power and decreases with axial length.