Proposed novel classification of circumscribed Lower-Grade Gliomas (cLGG) vs. infiltrating Lower-Grade Gliomas (iLGG): Correlations of radiological features and clinical outcomes

• Published in: World neurosurgery: X Vol. 23; p. 100356
• Main Authors: Khan, Ahsan Ali, Khalid, Muhammad Usman, Bajwa, Mohammad Hamza, Urooj, Faiza, Tahir, Izza, Angez, Meher, Zahid, Fahad, Saeed Baqai, Muhammad Waqas, Aftab, Kiran, Ansari, Shahabuddin, Khan, Ummul Wara, Ahmed, Ali Azan, Enam, Syed Ather
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2024; Elsevier
• Subjects: Circumscribed; Clinical outcomes; Glioma; Infiltrating; Lower-grade; Original; Radiological features; Circumscribed; Infiltrating; Glioma; Radiological features; Clinical outcomes; Lower-grade
• ISSN: 2590-1397; 2590-1397
• DOI: 10.1016/j.wnsx.2024.100356

We hypothesize that lower grade gliomas (LGG) can be identified and classified into two distinct subtypes: radiologically circumscribed Lower-Grade Gliomas (cLGG) and infiltrating Lower-Grade Gliomas (iLGG) based on radiological parameters and that these two different subtypes behave differently in terms of clinical outcomes. We conducted a retrospective cohort study on surgical patients diagnosed with lower grade glioma over five years. Patient records and MRIs were reviewed, and neurosurgeons classified tumors into cLGG and iLGG groups. From the 165 patients in our cohort, 30 (18.2%) patients were classified as cLGG and 135 (81.8%) patients were classified as iLGG Mean age in cLGG was 31.4 years while mean age in iLGG was 37.9 years (p = 0.004). There was significant difference in mean blood loss between cLGG and iLGG groups (270 and 411 ml respectively, p = 0.020). cLGG had a significantly higher proportion of grade II tumors (p < 0.001). The overall mean survival time for the iLGG group was 14.96 ± 1.23 months, and 18.77 ± 2.72 months for the cLGG group. In univariate cox regression, the survival difference between LGG groups was not significant (HR = 0.888, p = 0.581), however on multivariate regression cLGG showed a significant (aHZ = 0.443, p = 0.015) positive correlation with survival. Intense contrast enhancement (HZ = 41.468, p = 0.018), blood loss (HZ = 1.002, p = 0.049), and moderately high Ki-67 (HZ = 4.589, p = 0.032) were also significant on univariate analyses. Conclusion: cLGG and iLGG are radiologically distinct groups with separate prognoses, surgical experience, and associations.