Acetate‐ versus lactate‐buffered crystalloid solutions: A systematic review with meta‐analysis and trial sequential analysis
Objective There is a widespread use of buffered crystalloid solutions in clinical practice. However, guidelines do not distinguish between specific types of buffered solutions and clinical equipoise exists. We aimed to assess the desirable and undesirable effects of acetate‐ versus lactate‐buffered...
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Published in | Acta anaesthesiologica Scandinavica Vol. 66; no. 7; pp. 782 - 794 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Wiley Subscription Services, Inc
01.08.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Objective
There is a widespread use of buffered crystalloid solutions in clinical practice. However, guidelines do not distinguish between specific types of buffered solutions and clinical equipoise exists. We aimed to assess the desirable and undesirable effects of acetate‐ versus lactate‐buffered solutions in hospitalised patients.
Methods
We conducted a systematic review with meta‐analysis and trial sequential analysis of randomised clinical trials assessing the use of acetate‐ versus lactate‐buffered solutions for intravenous administration in hospitalised adults and children. The primary outcome was all‐cause short‐term mortality. We adhered to our published protocol, the Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) statement, the Cochrane Handbook and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology.
Results
We included five RCTs enrolling 390 patients. We found no statistically significant difference in short‐term mortality (random effects, risk ratio [RR] 0.29; 95% confidence interval [CI] 0.06–1.51, p = .14, I2 = 0%) or hospital length of stay (LOS) (random effects, mean difference [MD]—1.31, 95% CI −3.66 to 1.05, p = .28, I2 = 0%) between acetate‐ versus lactate‐buffered solutions. The quality of evidence was very low. Data regarding intensive care unit LOS were reported by three trials and duration of vasopressor treatment by one trial; none of these data allowed for pooling in meta‐analyses. No trials reported data on long‐term mortality, health‐related quality of life, adverse events, duration of mechanical ventilation or renal replacement therapy.
Conclusion
In this systematic review, we found very low quantity and quality of evidence on the use of acetate‐ versus lactate‐buffered solutions in hospitalised patients. |
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Bibliography: | Funding information This research project was funded by the Ehrenreich's foundation and Rigshospitalets research foundation. The funding organisations were not involved in the design, conduct, analyses or reporting of the review. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
ISSN: | 0001-5172 1399-6576 1399-6576 |
DOI: | 10.1111/aas.14076 |