Preoperative magnetic resonance imaging‐based prognostic model for mass‐forming intrahepatic cholangiocarcinoma

• Published in: Liver international Vol. 42; no. 4; pp. 930 - 941
• Main Authors: Rhee, Hyungjin, Choi, Sang Hyun, Park, Ji Hoon, Cho, Eun‐Suk, Yeom, Suk‐Keu, Park, Sumi, Han, Kyunghwa, Lee, Seung Soo, Park, Mi‐Suk
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2022
• Subjects: bile duct invasion; Bile Duct Neoplasms - diagnostic imaging; Bile Duct Neoplasms - surgery; Bile ducts; Bile Ducts, Intrahepatic - diagnostic imaging; Bile Ducts, Intrahepatic - pathology; carbohydrate antigen 19‐9; Cholangiocarcinoma; Cholangiocarcinoma - diagnostic imaging; Cholangiocarcinoma - surgery; Confidence intervals; Discrimination; Humans; lymph node metastasis; Lymph nodes; Magnetic Resonance Imaging; Medical imaging; Metastases; multiplicity; Neoplasm Staging; Patients; Prognosis; Resonance; Retrospective Studies; Survival; Training; Tumors; carbohydrate antigen 19-9; multiplicity; bile duct invasion; lymph node metastasis
• ISSN: 1478-3223; 1478-3231; 1478-3231
• DOI: 10.1111/liv.15196

Background & Aims As most staging systems for intrahepatic cholangiocarcinoma (iCCA) are based on pathological results, preoperative prognostic prediction is limited. This study aimed to develop and validate a prognostic model for the overall survival of patients with mass‐forming iCCA (MF‐iCCA) using preoperative magnetic resonance imaging (MRI) and clinical findings. Methods We enrolled a total of 316 patients who underwent preoperative MRI and surgical resection for treatment‐naive MF‐iCCA from six institutions, between January 2009 and December 2015. The subjects were randomly assigned to a training set (n = 208) or validation set (n = 108). The MRIs were independently reviewed by three abdominal radiologists. Using MRI and clinical findings, an MRI prognostic score was established. We compared the discrimination performance of MRI prognostic scores with those of conventional pathological staging systems. Results We developed an MRI prognostic score consisting of serum CA19‐9 and three MRI findings (tumour multiplicity, lymph node metastasis and bile duct invasion). The MRI prognostic score demonstrated good discrimination performance in both the training set (C‐index, 0.738; 95% confidence interval [CI], 0.698–0.780) and validation set (C‐index, 0.605; 95% CI, 0.526–0.680). In the validation set, MRI prognostic score showed no significant difference with AJCC 8th TNM stage, MEGNA score and Nathan’s stage. Conclusions Our MRI prognostic score for overall survival of MF‐iCCA showed comparable discriminatory performance with pathological staging systems and might be used to determine an optimal treatment strategy.