Cardiac remodeling from the fetus to adulthood
Prenatal cardiac remodeling refers to in utero changes in the fetal heart that occur as a response to an adverse intrauterine environment. In this article, we will review the main mechanisms leading to cardiac remodeling and dysfunction, summarizing and describing the major pathological conditions t...
Saved in:
Published in | Journal of clinical ultrasound Vol. 51; no. 2; pp. 249 - 264 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken, USA
John Wiley & Sons, Inc
01.02.2023
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Prenatal cardiac remodeling refers to in utero changes in the fetal heart that occur as a response to an adverse intrauterine environment. In this article, we will review the main mechanisms leading to cardiac remodeling and dysfunction, summarizing and describing the major pathological conditions that have been reported to be related to this in utero plastic adaptive process. We will also recap the current evidence regarding the persistence of fetal cardiac remodeling and dysfunction, both in infancy and later in adult life. Moreover, we will discuss primary, secondary, and tertiary preventive measures and future clinical and research aspects.
The named “second hit hypothesis” postulates that a predisposed individual ‐that has already suffered a first hit during fetal life‐, postnatally, will more easily fail to cope with a second hit and will be at major risk of cardiovascular disease/failure. |
---|---|
Bibliography: | Funding information Fundación Mutua Madrileña; Fundació Jesus Serra; Cerebra Foundation for the Brain Injured Child; Fondo Europeo de Desarrollo Regional (FEDER); ISCIII‐Subdirección General de Evaluación; Instituto de Salud Carlos III, Grant/Award Numbers: INT21/00027, PI20/00246 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0091-2751 1097-0096 |
DOI: | 10.1002/jcu.23336 |