Sex dimorphisms in coagulation: Implications in trauma‐induced coagulopathy and trauma resuscitation

Trauma‐induced coagulopathy (TIC) is one of the leading causes of preventable death in injured patients. Consequently, it is imperative to understand the mechanisms underlying TIC and how to mitigate this mortality. An opportunity for advancement stems from the awareness that coagulation demonstrate...

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Published inAmerican journal of hematology Vol. 99; no. S1; pp. S28 - S35
Main Authors Coleman, Julia R., Gumina, Richard, Hund, Thomas, Cohen, Mitchell, Neal, Matthew D., Townsend, Kristy, Kerlin, Bryce A.
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.04.2024
Wiley Subscription Services, Inc
Subjects
Blood Coagulation
Blood Coagulation Disorders
Blood Platelets
Coagulation
Female
Fibrinogen
Fibrinolysis
Hemostasis
Humans
Male
Sex
Sex Characteristics
Trauma
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Summary:Trauma‐induced coagulopathy (TIC) is one of the leading causes of preventable death in injured patients. Consequently, it is imperative to understand the mechanisms underlying TIC and how to mitigate this mortality. An opportunity for advancement stems from the awareness that coagulation demonstrates a strong sex‐dependent effect. Females exhibit a relative hypercoagulability compared to males, which persists after injury and confers improved outcomes. The mechanisms underlying sex dimorphisms in coagulation and its protective effect after injury have yet to be elucidated. This review explores sex dimorphisms in enzymatic hemostasis, fibrinogen, platelets, and fibrinolysis, with implications for resuscitation of patients with TIC. Sex dimorphisms in coagulation have significant implications in understanding and treating trauma‐induced coagulopathy. Don't miss this review by Coleman et al. on the clinical implications of sex‐specific differences in hemostatic capacity.
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ISSN:0361-8609
1096-8652
1096-8652
DOI:10.1002/ajh.27296