Anti‐inflammatory effect of octyl gallate in alveolar macrophages cells and mice with acute lung injury

• Published in: Journal of cellular physiology Vol. 235; no. 9; pp. 6073 - 6084
• Main Authors: Haute, Gabriela Viegas, Luft, Carolina, Antunes, Géssica Luana, Silveira, Josiane Silva, Souza Basso, Bruno, Costa, Mariana Severo, Levorse, Vitor Giancarlo Schneider, Kaiber, Daniela Benvenutti, Donadio, Márcio Vinícius Fagundes, Gracia‐Sancho, Jordi, Oliveira, Jarbas Rodrigues
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2020
• Subjects: acute lung injury; Acute Lung Injury - drug therapy; Acute Lung Injury - pathology; Alveoli; Animals; Chemical compounds; Chemokines; Cytokines; Disease Models, Animal; Fungicides; Gallic Acid - analogs & derivatives; Gallic Acid - pharmacology; Humans; In vivo methods and tests; Inflammation; Inflammation - drug therapy; Inflammation - pathology; Lipopolysaccharides; Lung - drug effects; Lung - pathology; Lung Injury - drug therapy; Lung Injury - genetics; Lung Injury - pathology; Lungs; Macrophages; Macrophages, Alveolar - drug effects; Macrophages, Alveolar - pathology; Mice; octyl gallate; Oxidative Stress - drug effects; Pharmacology; Phenolic compounds; Phenols; RAW 264.7 Cells; Respiratory distress syndrome; Respiratory therapy; Sepsis; octyl gallate; macrophages; inflammation; acute lung injury
• ISSN: 0021-9541; 1097-4652
• DOI: 10.1002/jcp.29536

Acute lung injury (ALI) is an inflammatory process, and has high incidence and mortality. ALI and the acute respiratory distress syndrome are two common complications worldwide that result in acute lung failure, sepsis, and death. Pro‐inflammatory substances, such as cytokines and chemokines, are responsible for activating the body's defense mechanisms and usually mediate inflammatory processes. Therefore, the research of substances that decrease the uncontrolled response of organism is seen as potential for patients with ALI. Octyl gallate (OG) is a phenolic compound with therapeutic actions namely antimicrobial, antiviral, and antifungal. In this study, we evaluated its action on lipopolysaccharide (LPS)‐activated alveolar macrophages RAW 264.7 cells and ALI in male mice. Our results demonstrated protective effects of OG in alveolar macrophages activated with LPS and mice with ALI. The OG treatment significantly decreased the inflammatory markers in both studies in vitro and in vivo. The data suggested that OG can act as an anti‐inflammatory agent for ALI. Octyl gallate treatment decreases inflammatory markers in LPS‐activated alveolar macrophages RAW 264.7 cells and attenuates inflammation in an acute lung injury model.