The silver lining: towards the responsible and limited usage of silver

• Published in: Journal of applied microbiology Vol. 123; no. 5; pp. 1068 - 1087
• Main Authors: Naik, K., Kowshik, M.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.11.2017
• Subjects: Alcohols; Animals; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antibiotics; Anticancer properties; Antioxidants; Antitumor activity; Bacteria; Biocompatibility; Bone growth; Bone healing; Dose-Response Relationship, Drug; Human body; Humans; Immunity; In vivo methods and tests; Infections; Ingestion; Inhalation; low concentration; Low concentrations; medical applications; Microbicides; nanosilver; Regeneration; Regeneration (physiology); Respiration; Respiratory tract; Respiratory tract diseases; Silver - chemistry; Silver - pharmacology; Stomach; Toxicity; Ulcers; Wound healing; nanosilver; inhalation; medical applications; ingestion; low concentration
• ISSN: 1364-5072; 1365-2672
• DOI: 10.1111/jam.13525

Summary Silver has attracted a lot of attention as a powerful, broad spectrum and natural antimicrobial agent since the ancient times because of its nontoxic nature to the human body at low concentrations. It has been used in treatment of various infections and ulcers, storage of water and prevention of bacterial growth on the surfaces and within materials. However, there are numerous medical and health benefits of colloidal or nanosilver apart from its microbicidal ability which as yet has not been fully embraced by the medical community. These include antiplatelet activity, antioxidant effect, anticancer activity, wound healing and bone regeneration, enhancement of immunity, and increase in antibiotic efficiency. Additionally silver also provides protection against alcohol toxicity, upper respiratory tract infections and stomach ailments. Although nanosilver has been proposed for various topical applications, its usage by ingestion and inhalation remains controversial due to the lack of detailed and precise toxicity information. These beneficial properties of silver can be utilized by using silver at very low concentrations which are not harmful to the human body and environment. The following review discusses the diverse medical applications of silver and further recommends human clinical studies for its in vivo usage.