“Subtotal” hemispherectomy in children with intractable focal epilepsy

• Published in: Epilepsia (Copenhagen) Vol. 55; no. 12; pp. 1926 - 1933
• Main Authors: Chugani, Harry T., Asano, Eishi, Juhász, Csaba, Kumar, Ajay, Kupsky, William J., Sood, Sandeep
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2014
• Subjects: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsies, Partial - diagnostic imaging; Epilepsies, Partial - pathology; Epilepsies, Partial - surgery; FDG PET; Female; Fluorodeoxyglucose F18; Hemispherectomy - methods; Humans; Infant; Infantile spasms; Longitudinal Studies; Magnetic Resonance Imaging; Male; Pediatric; Positron-Emission Tomography; Retrospective Studies; Seizure; Surgery; Treatment Outcome; Infantile spasms; Seizure; Pediatric; Surgery; FDG PET
• ISSN: 0013-9580; 1528-1167
• DOI: 10.1111/epi.12845

Summary Objective Cortical resections in epilepsy surgery tend to be larger in children, compared to adults, partly due to underlying pathology. Some children show unilateral multifocal seizure onsets involving much of the hemisphere. If there were a significant hemiparesis present, hemispherectomy would be the procedure of choice. Otherwise, it is preferable to spare the primary sensorimotor cortex. We report the results of “subtotal” hemispherectomy in 23 children. Methods All children (ages 1 year and 4 months to 14 years and 2 months) were operated on between 2001 and 2013 at Children's Hospital of Michigan (Detroit). Patients were evaluated with scalp video–electroencephalography (EEG), magnetic resonance imaging (MRI), 18F‐fluorodeoxyglucose–positron emission tomography (FDG‐PET) scans, and neuropsychological assessments when applicable. Subsequently, each case was discussed in a multidisciplinary epilepsy surgery conference, and a consensus was reached pertaining to candidacy for surgery and optimum surgical approach. The actual extent of resection was based on the results from subdural electrocorticography (ECoG) monitoring. The surgical outcome is based on International League Against Epilepsy (ILAE) classification (class 1–6). Results Among the 23 patients, 11 had epileptic spasms as their major seizure type; these were associated with focal seizures in 3 children. MRI showed focal abnormalities in 12 children. FDG‐PET was abnormal in all but one subject. All except two children underwent chronic subdural ECoG. Multiple subpial transections were performed over the sensorimotor cortex in three subjects. On histopathology, various malformations were seen in 9 subjects; the remainder showed gliosis alone (n = 12), porencephaly (n = 1), and gliosis with microglial activation (n = 1). Follow‐up ranged from 13 to 157 months (mean = 65 months). Outcomes consisted of class 1 (n = 17, 74%), class 2 (n = 2), class 3 (n = 1), class 4 (n = 1), and class 5 (n = 2). Significance Extensive unilateral resections sparing only sensorimotor cortex can be performed with excellent results in seizure control. Even with the presence of widespread unilateral epileptogenicity or anatomic/functional imaging abnormalities, complete hemispherectomy can often be avoided, particularly when there is little hemiparesis.