Physiological roles of human interleukin‐17 family
Interleukin‐17 s (IL‐17s) are well‐known proinflammatory cytokines, and their antagonists perform excellently in the treatment of inflammatory skin diseases such as psoriasis. However, their physiological functions have not been given sufficient attention by clinicians. IL‐17s can protect the host f...
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Published in | Experimental dermatology Vol. 33; no. 1; pp. e14964 - n/a |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Denmark
Wiley Subscription Services, Inc
01.01.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Interleukin‐17 s (IL‐17s) are well‐known proinflammatory cytokines, and their antagonists perform excellently in the treatment of inflammatory skin diseases such as psoriasis. However, their physiological functions have not been given sufficient attention by clinicians. IL‐17s can protect the host from extracellular pathogens, maintain epithelial integrity, regulate cognitive processes and modulate adipocyte activity through distinct mechanisms. Here, we present a systematic review concerning the physiological functions of IL‐17s. Our goal is not to negate the therapeutic effect of IL‐17 antagonists, but to ensure their safe use and reasonably explain the possible adverse events that may occur in their application. |
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Bibliography: | Yucong Liu, Ye Ouyang and Wanchun You have contributed equally to this work and share first authorship. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
ISSN: | 0906-6705 1600-0625 |
DOI: | 10.1111/exd.14964 |