Prognostic utility of pre‐transplantation [18F] fluorodeoxyglucose positron emission tomography/computed tomography in patients with diffuse large B‐cell lymphoma who underwent rituximab, dexamethasone, high‐dose cytarabine, carboplatin salvage chemotherapy

• Published in: British journal of haematology Vol. 188; no. 2; pp. 268 - 271
• Main Authors: Mesguich, Charles, Roch, Alexandre, Hindié, Elif, Milpied, Noël, Bordenave, Laurence, Tlili, Ghoufrane, Bouabdallah, Krimo
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.01.2020
• Subjects: 18‐ fluorodeoxyglucose; autologous stem cell transplantation; B-cell lymphoma; Carboplatin; Chemotherapy; Computed tomography; Cytarabine; Dexamethasone; diffuse large B‐cell lymphoma; Glycolysis; Hematology; Immunotherapy; Lymphoma; Monoclonal antibodies; Positron emission tomography; positron emission tomography/computed tomography; Rituximab; Survival; Targeted cancer therapy; Tomography; transplant; Transplantation; Transplants & implants; 18- fluorodeoxyglucose; transplant; positron emission tomography/computed tomography; diffuse large B-cell lymphoma; autologous stem cell transplantation
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/bjh.16144

Summary We analysed the outcomes of 62 patients with refractory/relapsed diffuse large B‐cell lymphoma (rrDLBCL) who had pre‐transplantation fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) after R‐DHAC (rituximab, dexamethasone, high‐dose cytarabine, carboplatin) salvage chemotherapy, and were evaluated using Deauville criteria and total lesion glycolysis (TLG). A positive pre‐transplantation PET/CT with Deauville score of 5 was associated with shorter progression‐free survival (PFS) (P = 0·01), while a Deauville score of 4 was not predictive of outcome. Only pre‐transplant TLG was significantly associated with both PFS (P = 0·005) and overall survival (P = 0·03). TLG deserves to be further investigated in prospective studies.