Seminal levels of angiotensin II and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients: Relation to fertility status

Several theories were proposed to explain the pathophysiology of varicocele‐related infertility seen in some patients. Our aim was to study the levels of angiotensin II in semen and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients in relation to their fertility status...

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Published inAndrologia Vol. 52; no. 3; pp. e13513 - n/a
Main Authors El‐Ariny, Ali F., El‐Garem, Yehia F., Eid, Amira Abulfotooh, Donia, Hanaa M., Aly, Rania G., Abdelmeniem, Iman Mohamed
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.04.2020
Subjects
Angiotensin
Angiotensin II
AT2R
Infertility
Motility
Semen
Sperm
varicocele
infertility
AT2R
angiotensin II
varicocele
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Summary:Several theories were proposed to explain the pathophysiology of varicocele‐related infertility seen in some patients. Our aim was to study the levels of angiotensin II in semen and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients in relation to their fertility status and to evaluate the influence of varicocelectomy on their levels in infertile varicocele patients. Thirty fertile and 30 infertile varicocele patients and 30 healthy controls were subjected to measurement of reproductive hormones, semen analysis, measurement of seminal angiotensin II and evaluation of angiotensin II type 2 receptor expression on spermatozoa. Infertile varicocele patients underwent varicocelectomy and were re‐evaluated for the same parameters after the operation. Sperm concentration, morphology, progressive motility, seminal angiotensin II and angiotensin II type 2 receptor expression were significantly lower in infertile varicocele patients compared with the other groups. Post‐operative values showed significant increase in the studied parameters compared with the pre‐operative values but not to other two groups. A significant positive correlation between angiotensin II type 2 receptor expression and progressive motility was detected in all studied groups. In conclusion, dysregulation of angiotensin II and angiotensin II type 2 receptor in varicocele patients may be involved in varicocele‐related infertility.
Bibliography:Funding information
This research was completely funded by the authors.
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ISSN:0303-4569
1439-0272
DOI:10.1111/and.13513