Estimating HLA haplotype frequencies from homozygous individuals – A Technical Report

We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation‐maximization algorithm, the errors were larger. However, our approach allows the uneq...

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Bibliographic Details
Published inInternational journal of immunogenetics Vol. 48; no. 6; pp. 490 - 495
Main Authors Seitz, Susanne, Lange, Vinzenz, Norman, Paul J., Sauter, Jürgen, Schmidt, Alexander H.
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.12.2021
Subjects
allele frequency
Alleles
donor registry
Gene Frequency
haplotype frequency
Haplotypes
Haplotypes - genetics
Histocompatibility antigen HLA
HLA
HLA Antigens - genetics
homozygosity
Humans
Registries
donor registry
HLA
haplotype frequency
homozygosity
allele frequency
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Summary:We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation‐maximization algorithm, the errors were larger. However, our approach allows the unequivocal detection of rare haplotypes.
Bibliography:Linked Letters: Nunes, J. M. et al.
and Seitz, S., et al.
https://doi.org/10.1111/iji.12555
https://doi.org/10.1111/iji.12556
2021
International Journal of Immunogenetic
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1744-3121
1744-313X
DOI:10.1111/iji.12553