Real‐world performance of the MiniMed 780G advanced hybrid closed loop system in Latin America: Substantial improvement in glycaemic control with each technology iteration of the MiniMed automated insulin delivery system

• Published in: Diabetes, obesity & metabolism Vol. 25; no. 6; pp. 1688 - 1697
• Main Authors: Grassi, Bruno, Gómez, Ana Maria, Calliari, Luis Eduardo, Franco, Denise, Raggio, Marcela, Riera, Francisca, Castro, Matias, McVean, Jennifer, Heuvel, Tim, Arrieta, Arcelia, Castañeda, Javier, Cohen, Ohad
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2023; Wiley Subscription Services, Inc
• Subjects: Automation; Blood Glucose - analysis; Blood Glucose Self-Monitoring; continuous glucose monitoring; Diabetes; Diabetes Mellitus, Type 1 - drug therapy; Glucose; Glucose - therapeutic use; Glucose monitoring; Glycemic Control; health economics; Humans; Hypoglycemic Agents - therapeutic use; Insulin; Insulin - therapeutic use; Insulin Infusion Systems; insulin pump therapy; Insulin, Regular, Human - therapeutic use; Latin America - epidemiology; real‐world evidence; Technology; type 1 diabetes; Latin America; type 1 diabetes; real-world evidence; continuous glucose monitoring; insulin pump therapy; health economics
• ISSN: 1462-8902; 1463-1326
• DOI: 10.1111/dom.15023

Aim We studied real‐world performance of MiniMed (MM) 780G system users from Argentina, Brazil, Colombia and Chile (geographical analysis), and the effect of each technology iteration of the MM system on glycaemic control (technology iteration analysis). Materials and Methods CareLink data from August 2020 to September 2022 were extracted. Endpoints included continuous glucose monitoring metrics. For the geographical analysis, aggregated endpoints for MM780G system users were calculated. For the technology iteration analysis, MM780G system user outcomes were compared with outcomes when the same individuals were still using the MM640G or MM670G system. Results On average, 1025 MM780G system users from the geographical analysis were followed for 136 (SD 135) days, spent 91.5 (14.3)% in advanced hybrid closed loop, showed a glucose management indicator (GMI) of 6.7 (0.3)%, a time in range between 70 and 180 mg/dl (TIR) of 76.5 (9.0)%, and a time below range 70 mg/dl (TBR) of 2.7 (2.1)%. The percentage of users reaching targets of GMI <7%, TIR >70% and TBR <4% was 80.8%, 78.1% and 80.1%, respectively. The technology iteration analysis on users transitioning from MM640G to MM780G system (N = 381) showed 0.4% decrease in GMI (7.1% to 6.7%, p < .0001), 10.7% increase in TIR (65.9% to 76.6%, p < .0001), while TBR remained. The percentage of insulin delivered automatically increased as well (47.5%‐57.7%, p < .0001). Users transitioning from MM670G system (N = 78) showed a similar but less pronounced pattern. Conclusions Real‐world Latin American MM780G users on average showed good glucose control, achieving international targets. Glycaemic control increased with every technology iteration of the MM system, providing more automation each time.