Recent Advances in Pathology: the 2022 Annual Review Issue of The Journal of Pathology

• Published in: The Journal of pathology Vol. 257; no. 4; pp. 379 - 382
• Main Authors: Herrington, C Simon, Poulsom, Richard, Pillay, Nischalan, Bankhead, Peter, Coates, Philip J
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.07.2022; Wiley Subscription Services, Inc
• Subjects: 3D reconstruction; adult stem cells; artificial intelligence; Asthma; biomarkers; Breast cancer; cancer; cancer‐adjacent tissues; cancer‐associated fibroblasts; chromothripsis; chronic obstructive pulmonary disease; clonal dynamics; clonality analysis; colon; computational pathology; Computer applications; convolutional neural networks; copy number aberrations; copy number signatures; cystic fibrosis; data repository; desquamation; digital pathology; DNA sequencing; epidermal inflammation; epidermis; epithelial transition states; extrachromosomal DNA; Fibroblasts; field cancerisation; filaggrin; functional pathology; genomics; haemopoietic stem cells; host; Humans; idiopathic pulmonary fibrosis; image analysis; image processing; Immune checkpoint inhibitors; immune system; immunotherapy; in situ hybridisation; in vivo models; intestinal stem cells; intra‐tumour heterogeneity; kallikrein‐related peptidases; lineage tracing; lung atlas; lung diseases; lung progenitors; lung stem cells; machine learning; metabolome; microbiome; Microenvironments; Mutation; mutational signatures; Neoplasms - genetics; Neoplasms - pathology; open science; PAR1; PAR2; Pathology; patient stratification; prediction; prognosis; protease inhibitors; Proteolysis; proteolytic cascades; Pulmonary fibrosis; quantitative methods; QuPath; Reviews; single cell DNA sequencing; single cell RNA sequencing; single cell transcriptomics; skin diseases; skin physiology; Software; structural variants; subclone; Tumor Microenvironment - genetics; Tumors; tumour evolution; tumour phylogeny; United Kingdom; virtual slide; Whole genome sequencing; whole‐slide imaging; whole‐slide scanning; United Kingdom; whole-slide scanning; software; single cell transcriptomics; extrachromosomal DNA; lineage tracing; image analysis; artificial intelligence; 3D reconstruction; host; immune system; convolutional neural networks; filaggrin; epidermis; image processing; in vivo models; lung atlas; haemopoietic stem cells; tumour phylogeny; cancer-adjacent tissues; single cell RNA sequencing; biomarkers; clonal dynamics; asthma; proteolytic cascades; idiopathic pulmonary fibrosis; immune checkpoint inhibitors; microbiome; adult stem cells; whole genome sequencing; cancer-associated fibroblasts; digital pathology; intestinal stem cells; copy number signatures; prediction; lung progenitors; DNA sequencing; field cancerisation; skin physiology; QuPath; whole-slide imaging; data repository; patient stratification; kallikrein-related peptidases; epithelial transition states; epidermal inflammation; intra-tumour heterogeneity; cystic fibrosis; desquamation; chromothripsis; immunotherapy; protease inhibitors; genomics; clonality analysis; functional pathology; subclone; skin diseases; virtual slide; lung diseases; open science; computational pathology; quantitative methods; breast cancer; machine learning; prognosis; structural variants; in situ hybridisation; copy number aberrations; PAR2; single cell DNA sequencing; PAR1; mutational signatures; colon; cancer; lung stem cells; metabolome; tumour evolution; chronic obstructive pulmonary disease
• ISSN: 0022-3417; 1096-9896; 1096-9896
• DOI: 10.1002/path.5972

The 2022 Annual Review Issue of The Journal of Pathology, Recent Advances in Pathology, contains 15 invited reviews on research areas of growing importance in pathology. This year, the articles include those that focus on digital pathology, employing modern imaging techniques and software to enable improved diagnostic and research applications to study human diseases. This subject area includes the ability to identify specific genetic alterations through the morphological changes they induce, as well as integrating digital and computational pathology with ‘omics technologies. Other reviews in this issue include an updated evaluation of mutational patterns (mutation signatures) in cancer, the applications of lineage tracing in human tissues, and single cell sequencing technologies to uncover tumour evolution and tumour heterogeneity. The tissue microenvironment is covered in reviews specifically dealing with proteolytic control of epidermal differentiation, cancer‐associated fibroblasts, field cancerisation, and host factors that determine tumour immunity. All of the reviews contained in this issue are the work of invited experts selected to discuss the considerable recent progress in their respective fields and are freely available online (https://onlinelibrary.wiley.com/journal/10969896). © 2022 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.