Bioactive Spirobisnaphthalenes and Lactones from a Cup Fungus Plectania sp. Collected in the Tibet Plateau Region
Five new spirobisnaphthalenes (1–5), one new tetralone derivative (6), and six new lactones (7–12) together with the known compound urnucratin C (13) have been isolated from the solid culture of the cup fungus Plectania sp. The structures of the new compounds were unambiguously elucidated on the bas...
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Published in | European journal of organic chemistry Vol. 2016; no. 25; pp. 4338 - 4346 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WEINHEIM
Blackwell Publishing Ltd
01.09.2016
Wiley Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Five new spirobisnaphthalenes (1–5), one new tetralone derivative (6), and six new lactones (7–12) together with the known compound urnucratin C (13) have been isolated from the solid culture of the cup fungus Plectania sp. The structures of the new compounds were unambiguously elucidated on the basis of one‐ and two‐dimensional NMR spectroscopy, high‐resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Compounds 1–6 were found to be active against Staphylococcus aureus, methicillin‐resistant S. aureus (MRSA), Bacillus subtilis, and Pseudomonas aeruginosa. In addition, the cytotoxicities of 1–13 were evaluated against the HepG2 and K562 cell lines by using the CCK8 assay. Compounds 1–3 and 13 showed moderate cytotoxicity against HepG2 and K562 with IC50 values in the range 10.7–38.5 µm. This is the first report of secondary metabolites from this cup fungus.
Twelve new natural products (1–12) and the known urnucratin C (13) have been isolated from the solid culture of the cup fungus Plectania sp. and their structures unambiguously elucidated by spectroscopic methods. Compounds 1–6 were found to show antibacterial activity and compounds 1–3 and 13 showed moderate cytotoxicity against the HepG2 and K562 cell lines. |
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Bibliography: | istex:60E680ABD62F90C1388ABDFA65F6775F31FA016B the Ministry of Science and Technology of China - No. 2012FY111600 ArticleID:EJOC201600562 ark:/67375/WNG-5D1S3T9T-S Supporting Information the National Nature Science Foundation - No. 21472233 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1434-193X 1099-0690 |
DOI: | 10.1002/ejoc.201600562 |