The positive rates of hepatitis B surface antibody in youth after booster vaccination: a 4-year follow-up study with large sample

• Published in: Bioscience reports Vol. 41; no. 9; p. 1
• Main Authors: Zhu, Xia, Wang, Juan, Wang, Ming, Du, Ling-Yao, Ji, Yu-Lin, Zhang, Xuan, Tang, Hong
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd The Biochemical Society 30.09.2021; Portland Press Ltd
• Subjects: Adolescent; Age Factors; Age groups; Antibodies; Biomarkers - blood; Child; Child, Preschool; Family medical history; Female; Females; Follow-Up Studies; Gastrointestinal, Renal & Hepatic Systems; Gender; Hepatitis; Hepatitis B; Hepatitis B - immunology; Hepatitis B - prevention & control; Hepatitis B - virology; Hepatitis B Antibodies - blood; Hepatitis B Surface Antigens - immunology; Hepatitis B Vaccines - administration & dosage; Hepatitis B virus - drug effects; Hepatitis B virus - immunology; Humans; Immunization; Immunization, Secondary; Immunology & Inflammation; Infant; Infections; Laboratories; Maintenance; Male; Medical research; Statistical analysis; Time Factors; Treatment Outcome; Vaccines; Vaccines, Synthetic - administration & dosage; Virology; China; anti-HBs; Booster vaccination; youths; positive rates
• ISSN: 0144-8463; 1573-4935
• DOI: 10.1042/BSR20210182

Hepatitis B virus (HBV) infection is still a public issue in the world. Hepatitis B vaccination is widely used as an effective measure to prevent HBV infection. This large-sample study aimed to evaluate the positive rates of hepatitis B surface antibody (anti-HBs) in youth after booster vaccination. A total of 37788 participants were divided into two groups according to the baseline levels of anti-HBs before booster vaccination: the negative group (anti-HBs(-)) and the positive group (anti-HBs(+)). Participants were tested for anti-HBs levels after receiving a booster vaccine at 1 and 4 years. The positive rates of anti-HBs were 34.50%, 73.80% and 67.32% before booster vaccination at 1 and 4 years after vaccination, respectively. At 4 years after the booster vaccination, the positive rates of 13-18 years were 47.54%, which was the lowest level among all youth age groups. In the anti-HBs(-) group, the positive conversion rates of anti-HBs were 74.62% at 1 year after receiving a booster vaccine, and 67.66% at 4 years after vaccination. In the anti-HBs(+) group, the positive maintenance rates of anti-HBs were 70.16% after 1 year, and 66.66% after 4 years. Compared with the baseline anti-HBs (+) group, the positive rates of the baseline anti-HBs(-) group were higher at 1 and 4 years after receiving the booster vaccine. The positive rates of anti-HBs declined over time, especially the positive maintenance rates were the lowest at age of 13-18 years.